| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50001447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597393 (CHEMBL1037216) |
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| EC50 | 64.8±n/a nM |
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| Citation |  Valant, C; Maillet, E; Bourguignon, JJ; Bucher, B; Utard, V; Galzi, JL; Hibert, M Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration. J Med Chem52:5999-6011 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43868.63 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Neurokinin NK2 TACR2 Murine::P16610 |
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| Residue: | 390 |
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| Sequence: | MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
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| BDBM50001447 |
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| n/a |
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| Name | BDBM50001447 |
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| Synonyms: | CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(NeurokininA) |
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| Type | Small organic molecule |
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| Emp. Form. | C50H80N14O14S |
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| Mol. Mass. | 1133.321 |
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| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)C)C(N)=O |
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| Structure | 
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