Reaction Details |
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Target | Carbonic anhydrase 4 |
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Ligand | BDBM50303034 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_597002 (CHEMBL1041846) |
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Ki | 3905±n/a nM |
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Citation | Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma. Bioorg Med Chem Lett19:6565-70 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 4 |
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Name: | Carbonic anhydrase 4 |
Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
Type: | Enzyme |
Mol. Mass.: | 35037.98 |
Organism: | Homo sapiens (Human) |
Description: | P22748 |
Residue: | 312 |
Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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BDBM50303034 |
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n/a |
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Name | BDBM50303034 |
Synonyms: | CHEMBL571337 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-carbamic acid 2,3-bis-nitrooxy-propyl ester |
Type | Small organic molecule |
Emp. Form. | C14H20N4O12S3 |
Mol. Mass. | 532.523 |
SMILES | CCN([C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)C(=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O |r| |
Structure |
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