| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM50378636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610636 (CHEMBL1069650) |
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| IC50 | 252±n/a nM |
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| Citation |  Wu, Y; Tai, HH; Cho, H Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. Bioorg Med Chem18:1428-33 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM50378636 |
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| n/a |
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| Name | BDBM50378636 |
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| Synonyms: | CHEMBL607870 | US8637558, 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13NO5S |
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| Mol. Mass. | 355.365 |
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| SMILES | OC1=NC(=O)C(S1)=Cc1ccc(OCc2ccc3OCOc3c2)cc1 |w:7.8,t:1| |
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| Structure | 
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