| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
|---|
| Ligand | BDBM50313959 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_615503 (CHEMBL1105981) |
|---|
| EC50 | 187±n/a nM |
|---|
| Citation |  Goble, SD; Wang, L; Howell, KL; Bansal, A; Berger, R; Brockunier, L; DiSalvo, J; Feighner, S; Harper, B; He, J; Hurley, A; Hreniuk, D; Parmee, E; Robbins, M; Salituro, G; Sanfiz, A; Streckfuss, E; Watkins, E; Weber, AE; Struthers, M; Edmondson, SD Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles. Bioorg Med Chem Lett20:1895-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-3 adrenergic receptor |
|---|
| Name: | Beta-3 adrenergic receptor |
|---|
| Synonyms: | ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 43534.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 408 |
|---|
| Sequence: | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
|
|
|
|---|
| BDBM50313959 |
|---|
| n/a |
|---|
| Name | BDBM50313959 |
|---|
| Synonyms: | (R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)biphenyl-4-carboxamide | CHEMBL1089734 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27N3O2 |
|---|
| Mol. Mass. | 437.5329 |
|---|
| SMILES | O[C@@H](CNCCc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1)c1cccnc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
