| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
|---|
| Ligand | BDBM50314797 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_627223 (CHEMBL1110792) |
|---|
| EC50 | 49000±n/a nM |
|---|
| Citation |  Selvam, C; Oueslati, N; Lemasson, IA; Brabet, I; Rigault, D; Courtiol, T; Cesarini, S; Triballeau, N; Bertrand, HO; Goudet, C; Pin, JP; Acher, FC A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. J Med Chem53:2797-813 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 2 |
|---|
| Name: | Metabotropic glutamate receptor 2 |
|---|
| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 95584.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14416 |
|---|
| Residue: | 872 |
|---|
| Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
|
|
|
|---|
| BDBM50314797 |
|---|
| n/a |
|---|
| Name | BDBM50314797 |
|---|
| Synonyms: | (3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosphinyl]-2-chloropropanoic Acid | CHEMBL1076865 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H13ClNO6P |
|---|
| Mol. Mass. | 273.608 |
|---|
| SMILES | N[C@@H](CCP(O)(=O)CC(Cl)C(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
