| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50316126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_623483 (CHEMBL1113554) |
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| IC50 | 18000±n/a nM |
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| Citation |  Al-Omary, FA; Abou-Zeid, LA; Nagi, MN; Habib, el-SE; Abdel-Aziz, AA; El-Azab, AS; Abdel-Hamide, SG; Al-Omar, MA; Al-Obaid, AM; El-Subbagh, HI Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem18:2849-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50316126 |
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| n/a |
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| Name | BDBM50316126 |
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| Synonyms: | Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cetamide | Cetapred | FML-S | Klaron | Metimyd | N-Acetyl-4-amino-benzenesulfonamide | Ocusulf-10 | Ocusulf-30 | Predamide | Predsulfair | SULF-10 | SULF-15 | SULFACETAMIDE | Sulfacel-15 | Sulfacetamide, 1 | Sulfair-15 | Sulphacetamide | Sulphrin | Sulster | Sulten-10 | Vasocidin |
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| Type | Small organic molecule |
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| Emp. Form. | C8H10N2O3S |
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| Mol. Mass. | 214.242 |
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| SMILES | CC(=O)NS(=O)(=O)c1ccc(N)cc1 |
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| Structure | 
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