| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucocorticoid receptor |
|---|
| Ligand | BDBM50316555 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_631258 (CHEMBL1114665) |
|---|
| IC50 | 86.0±n/a nM |
|---|
| Citation |  Bai, M; Carr, G; Deorazio, RJ; Friedrich, TD; Dobritsa, S; Fitzpatrick, K; Guzzo, PR; Kitchen, DB; Lynch, MA; Peace, D; Sajad, M; Usyatinsky, A; Wolf, MA 5-Functionalized indazoles as glucocorticoid receptor agonists. Bioorg Med Chem Lett20:3017-20 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucocorticoid receptor |
|---|
| Name: | Glucocorticoid receptor |
|---|
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85656.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04150 |
|---|
| Residue: | 777 |
|---|
| Sequence: | MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
|
|
|
|---|
| BDBM50316555 |
|---|
| n/a |
|---|
| Name | BDBM50316555 |
|---|
| Synonyms: | 2,2,2-trifluoro-1-(4-fluorophenyl)-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)ethanol | 2,2,2-trifluoro-1-(4-fluorophenyl)-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethan-1-ol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H13F5N2O |
|---|
| Mol. Mass. | 404.3327 |
|---|
| SMILES | OC(c1ccc(F)cc1)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
