Reaction Details |
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Target | Transcription factor p65 |
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Ligand | BDBM50317859 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_629938 (CHEMBL1109182) |
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IC50 | 3700±n/a nM |
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Citation | Ren, Y; Kardono, LB; Riswan, S; Chai, H; Farnsworth, NR; Soejarto, DD; Carcache de Blanco, EJ; Kinghorn, AD Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. J Nat Prod73:949-55 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transcription factor p65 |
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Name: | Transcription factor p65 |
Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
Type: | Enzyme |
Mol. Mass.: | 60211.92 |
Organism: | Homo sapiens (Human) |
Description: | Q04206 |
Residue: | 551 |
Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
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BDBM50317859 |
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n/a |
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Name | BDBM50317859 |
Synonyms: | CHEMBL1099162 | artobiloxanthone |
Type | Small organic molecule |
Emp. Form. | C25H22O7 |
Mol. Mass. | 434.438 |
SMILES | CC(=C)[C@H]1Cc2c(O)c3c(oc2-c2c(O)cc(O)c(O)c12)c1C=CC(C)(C)Oc1cc3=O |r,c:25| |
Structure |
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