| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 2 |
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| Ligand | BDBM50318264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_629329 (CHEMBL1104009) |
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| Ki | 43±n/a nM |
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| Citation |  Lolli, ML; Giordano, C; Pickering, DS; Rolando, B; Hansen, KB; Foti, A; Contreras-Sanz, A; Amir, A; Fruttero, R; Gasco, A; Nielsen, B; Johansen, TN 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. J Med Chem53:4110-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 2 |
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| Name: | Glutamate receptor 2 |
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| Synonyms: | GRIA2_RAT | Glur2 | Glutamate receptor AMPA 2/4 | Glutamate receptor ionotropic, AMPA 2 | Gria2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98691.74 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_936441 |
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| Residue: | 883 |
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| Sequence: | MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLL
DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
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| BDBM50318264 |
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| n/a |
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| Name | BDBM50318264 |
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| Synonyms: | (+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)propionicAcid |
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| Type | Small organic molecule |
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| Emp. Form. | C5H7N3O4 |
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| Mol. Mass. | 173.1268 |
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| SMILES | NC(Cc1no[nH]c1=O)C(O)=O |
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| Structure | 
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