| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 2 |
|---|
| Ligand | BDBM50318266 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_629331 (CHEMBL1104011) |
|---|
| Ki | >1000000±n/a nM |
|---|
| Citation |  Lolli, ML; Giordano, C; Pickering, DS; Rolando, B; Hansen, KB; Foti, A; Contreras-Sanz, A; Amir, A; Fruttero, R; Gasco, A; Nielsen, B; Johansen, TN 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. J Med Chem53:4110-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor ionotropic, kainate 2 |
|---|
| Name: | Glutamate receptor ionotropic, kainate 2 |
|---|
| Synonyms: | GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 102478.61 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_936439 |
|---|
| Residue: | 908 |
|---|
| Sequence: | MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
|
|
|
|---|
| BDBM50318266 |
|---|
| n/a |
|---|
| Name | BDBM50318266 |
|---|
| Synonyms: | (+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pentanoicAcid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H11N3O4 |
|---|
| Mol. Mass. | 201.1799 |
|---|
| SMILES | NC(CCCc1no[nH]c1=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
