Reaction Details |
| Report a problem with these data |
Target | Lysosomal acid lipase/cholesteryl ester hydrolase |
---|
Ligand | BDBM50318693 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_633497 (CHEMBL1119694) |
---|
IC50 | 496±n/a nM |
---|
Citation | Rosenbaum, AI; Cosner, CC; Mariani, CJ; Maxfield, FR; Wiest, O; Helquist, P Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem53:5281-9 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Lysosomal acid lipase/cholesteryl ester hydrolase |
---|
Name: | Lysosomal acid lipase/cholesteryl ester hydrolase |
Synonyms: | LICH_HUMAN | LIPA |
Type: | PROTEIN |
Mol. Mass.: | 45422.01 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_633497 |
Residue: | 399 |
Sequence: | MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI
LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS
RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG
FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL
KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV
KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI
TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
|
|
|
BDBM50318693 |
---|
n/a |
---|
Name | BDBM50318693 |
Synonyms: | 4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl Piperidine-1-carboxylate | CHEMBL1085855 |
Type | Small organic molecule |
Emp. Form. | C12H18N4O2S |
Mol. Mass. | 282.362 |
SMILES | O=C(Oc1nsnc1N1CCCC1)N1CCCCC1 |
Structure |
|