| Reaction Details |
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 | Report a problem with these data |
| Target | KiSS-1 receptor |
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| Ligand | BDBM50322309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_642624 (CHEMBL1176639) |
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| IC50 | 7.9±n/a nM |
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| Citation |  Kobayashi, T; Sasaki, S; Tomita, N; Fukui, S; Nakayama, M; Kiba, A; Kusaka, M; Matsumoto, S; Yamaguchi, M; Itoh, F; Baba, A 2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats. Bioorg Med Chem18:5157-71 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| KiSS-1 receptor |
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| Name: | KiSS-1 receptor |
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| Synonyms: | AXOR12 | G-protein Coupled Receptor 54 | G-protein coupled receptor 54 (GPR54) | GPR54 | Hypogonadotropin-1 | KISS1R | KISSR_HUMAN | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42613.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assay was performed using membranes from the CHO cell transfectants. |
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| Residue: | 398 |
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| Sequence: | MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGN
SLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY
IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL
HRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAP
ADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYA
AYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPH
AELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
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| BDBM50322309 |
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| n/a |
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| Name | BDBM50322309 |
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| Synonyms: | CHEMBL1170903 | N-[3-Cyano-6-(4-fluoro-2-hydroxyphenyl)-4-(3-{[(2S)-pyrrolidin-2-ylacetyl]amino}phenyl)pyridin-2-yl]furan-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24FN5O4 |
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| Mol. Mass. | 525.5304 |
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| SMILES | Oc1cc(F)ccc1-c1cc(-c2cccc(NC(=O)C[C@@H]3CCCN3)c2)c(C#N)c(NC(=O)c2ccco2)n1 |r| |
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| Structure | 
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