| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50322695 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_642078 (CHEMBL1176110) |
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| IC50 | 1770±n/a nM |
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| Citation |  Seto, S; Okada, K; Kiyota, K; Isogai, S; Iwago, M; Shinozaki, T; Kitamura, Y; Kohno, Y; Murakami, K Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone. J Med Chem53:5012-24 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57593.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1453700 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50322695 |
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| n/a |
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| Name | BDBM50322695 |
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| Synonyms: | 4,6-Bis(benzylthio)-2-(methylthio)pyrimidine-5-carboxylic Acid | CHEMBL1172425 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N2O2S3 |
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| Mol. Mass. | 414.564 |
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| SMILES | CSc1nc(SCc2ccccc2)c(C(O)=O)c(SCc2ccccc2)n1 |
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| Structure | 
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