| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein phosphatase alpha |
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| Ligand | BDBM50326560 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_661804 (CHEMBL1252120) |
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| pH | 5±n/a |
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| IC50 | 108000±n/a nM |
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| Comments | extracted |
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| Citation |  Homan, KT; Balasubramaniam, D; Zabell, AP; Wiest, O; Helquist, P; Stauffacher, CV Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening. Bioorg Med Chem18:5449-56 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein phosphatase alpha |
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| Name: | Receptor-type tyrosine-protein phosphatase alpha |
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| Synonyms: | PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 90719.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18433 |
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| Residue: | 802 |
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| Sequence: | MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
YEFCYKVVQEYIDAFSDYANFK
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| BDBM50326560 |
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| n/a |
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| Name | BDBM50326560 |
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| Synonyms: | 2-amino-3-(5-oxo-5H-benzo[a]phenoxazin-10-yl)propanoic acid | CHEMBL1254362 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14N2O4 |
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| Mol. Mass. | 334.3255 |
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| SMILES | NC(Cc1ccc2oc3cc(=O)c4ccccc4c3nc2c1)C(O)=O |
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| Structure | 
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