| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein phosphatase alpha |
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| Ligand | BDBM50326559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_661806 (CHEMBL1252122) |
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| pH | 7±n/a |
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| IC50 | 3600±n/a nM |
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| Comments | extracted |
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| Citation |  Homan, KT; Balasubramaniam, D; Zabell, AP; Wiest, O; Helquist, P; Stauffacher, CV Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening. Bioorg Med Chem18:5449-56 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein phosphatase alpha |
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| Name: | Receptor-type tyrosine-protein phosphatase alpha |
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| Synonyms: | PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 90719.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18433 |
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| Residue: | 802 |
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| Sequence: | MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
YEFCYKVVQEYIDAFSDYANFK
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| BDBM50326559 |
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| n/a |
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| Name | BDBM50326559 |
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| Synonyms: | 4-(9,10-dioxo-4-(phenylamino)-5,8,9,10-tetrahydroanthracen-1-ylamino)benzenesulfonic acid | CHEMBL1254283 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20N2O5S |
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| Mol. Mass. | 472.512 |
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| SMILES | OS(=O)(=O)c1ccc(Nc2ccc(Nc3ccccc3)c3C(=O)C4=C(CC=CC4)C(=O)c23)cc1 |c:27,t:24| |
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| Structure | 
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