| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM50272865 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_661995 (CHEMBL1251643) |
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| IC50 | 4813±n/a nM |
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| Citation |  Chimenti, F; Secci, D; Bolasco, A; Chimenti, P; Granese, A; Carradori, S; Maccioni, E; Cardia, MC; Yáñez, M; Orallo, F; Alcaro, S; Ortuso, F; Cirilli, R; Ferretti, R; Distinto, S; Kirchmair, J; Langer, T Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem18:5063-70 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
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| Type: | Protein |
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| Mol. Mass.: | 59689.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21397 |
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| Residue: | 527 |
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| Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
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| BDBM50272865 |
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| n/a |
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| Name | BDBM50272865 |
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| Synonyms: | 1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-((S)-2-methylcyclohexylidene)hydrazine | CHEMBL1242992 | CHEMBL497675 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17F2N3S |
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| Mol. Mass. | 321.388 |
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| SMILES | C[C@H]1CCCCC1=NNc1nc(cs1)-c1ccc(F)cc1F |r,w:7.8| |
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| Structure | 
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