| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
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| Ligand | BDBM50334998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_702705 (CHEMBL1657779) |
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| IC50 | 880±n/a nM |
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| Citation |  Kohara, A; Doihara, H; Saita, K; Aota, M Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors. J Med Chem54:387-91 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 1 |
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| Name: | Sodium- and chloride-dependent glycine transporter 1 |
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| Synonyms: | GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 71066.17 |
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| Organism: | attus norvegicus (Rat) |
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| Description: | Glycine-1-transporter 0 HUMAN::P28572 |
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| Residue: | 638 |
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| Sequence: | MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPY
LCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVV
STYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALS
GNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRG
VKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQI
FYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVD
VSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEV
GNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIM
YIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGW
AVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAP
TTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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| BDBM50334998 |
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| n/a |
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| Name | BDBM50334998 |
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| Synonyms: | 3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazole | CHEMBL1649949 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N3 |
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| Mol. Mass. | 311.3798 |
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| SMILES | Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1 |
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| Structure | 
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