| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Ligand | BDBM50335104 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_702838 (CHEMBL1655368) |
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| IC50 | 139000±n/a nM |
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| Citation |  Shi, K; Huang, Q; Huang, Y; Lee, TC; Yu, H Reducing the brittleness of zein films through chemical modification. J Agric Food Chem59:56-61 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Synonyms: | DHFR-TS | DRTS_LEIMA | Thymidylate synthase (TS) |
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| Type: | Protein |
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| Mol. Mass.: | 58691.04 |
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| Organism: | Leishmania major |
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| Description: | P07382 |
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| Residue: | 520 |
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| Sequence: | MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGQR
AAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLT
RIYATAPACTRFFPFPPENAATAWDLASSQGRRKSEAEGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVP
HAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV
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| BDBM50335104 |
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| n/a |
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| Name | BDBM50335104 |
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| Synonyms: | 3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-yl)propan-1-one | CHEMBL1650287 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H9N3OS2 |
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| Mol. Mass. | 239.317 |
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| SMILES | Nc1nnc(CCC(=O)c2cccs2)s1 |
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| Structure | 
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