| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidase |
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| Ligand | BDBM50378857 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_705366 (CHEMBL1662791) |
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| pH | 5.5±n/a |
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| IC50 | 7400±n/a nM |
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| Comments | extracted |
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| Citation |  Lemaire, S; Glupczynski, Y; Duval, V; Joris, B; Tulkens, PM; Van Bambeke, F Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother53:2289-97 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidase |
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| Name: | Peptidase |
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| Synonyms: | MecA | Pbp2a | Penicillin binding protein 2 prime | Penicillin binding protein 2' | Penicillin binding protein 2a (PBP2a) | Penicillin-binding protein 2 prime | Penicillin-binding protein 2' |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76113.18 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_677175 |
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| Residue: | 668 |
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| Sequence: | MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEV
EMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKED
GMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSK
KDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETES
RNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVT
IVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLAL
VSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLD
DKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFE
KGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALEN
NGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGT
AELKMKQGETGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENG
NKKYDIDE
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| BDBM50378857 |
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| n/a |
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| Name | BDBM50378857 |
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| Synonyms: | CEFTOBIPROLE | Zeftera | Zevtera |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N8O6S2 |
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| Mol. Mass. | 534.569 |
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| SMILES | Nc1nc(ns1)C(N=O)C(=O)N[C@H]1[C@H]2SCC(C=C3CCN([C@@H]4CCNC4)C3=O)=C(N2C1=O)C(O)=O |r,w:17.17,c:31| |
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| Structure | 
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