| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50342020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743625 (CHEMBL1768168) |
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| IC50 | 342±n/a nM |
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| Citation |  Giuliani, G; Cappelli, A; Matarrese, M; Masiello, V; Turolla, EA; Monterisi, C; Fazio, F; Anzini, M; Pericot Mohr, G; Riitano, D; Finetti, F; Morbidelli, L; Ziche, M; Giorgi, G; Vomero, S Non-peptide NK1 receptor ligands based on the 4-phenylpyridine moiety. Bioorg Med Chem19:2242-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50342020 |
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| n/a |
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| Name | BDBM50342020 |
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| Synonyms: | CHEMBL1765493 | N-[3,5-Bis(trifluoromethyl)benzyl]-2-methyl-4-phenylnicotinamide 1-oxide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16F6N2O2 |
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| Mol. Mass. | 454.3651 |
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| SMILES | Cc1c(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(cc[n+]1[O-])-c1ccccc1 |
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| Structure | 
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