| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50342047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743741 (CHEMBL1767555) |
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| Ki | 1920±n/a nM |
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| Citation |  Donohue, SR; Dannals, RF; Halldin, C; Pike, VW N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. J Med Chem54:2961-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50342047 |
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| n/a |
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| Name | BDBM50342047 |
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| Synonyms: | 4-Cyano-N-(4-cyanotetrahydro-2H-pyran-4-yl)-1-(2-iodophenyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide | CHEMBL1765818 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20IN5O3 |
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| Mol. Mass. | 553.3518 |
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| SMILES | COc1ccc(cc1)-c1c(C#N)c(nn1-c1ccccc1I)C(=O)NC1(CCOCC1)C#N |
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| Structure | 
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