| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50289137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_761930 (CHEMBL1817449) |
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| Ki | 880±n/a nM |
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| Citation |  Dolusic, E; Larrieu, P; Moineaux, L; Stroobant, V; Pilotte, L; Colau, D; Pochet, L; Van den Eynde, B; Masereel, B; Wouters, J; Frédérick, R Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J Med Chem54:5320-34 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47874.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_825691 |
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| Residue: | 406 |
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| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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| BDBM50289137 |
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| n/a |
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| Name | BDBM50289137 |
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| Synonyms: | 6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | CHEMBL355606 | US10155972, Compound 680C91 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11FN2 |
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| Mol. Mass. | 238.2596 |
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| SMILES | Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1 |
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| Structure | 
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