| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione reductase, mitochondrial |
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| Ligand | BDBM17657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_767322 (CHEMBL1825434) |
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| IC50 | 53700±n/a nM |
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| Citation |  Çakmak, R; Durdagi, S; Ekinci, D; Sentürk, M; Topal, G Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Bioorg Med Chem Lett21:5398-402 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutathione reductase, mitochondrial |
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| Name: | Glutathione reductase, mitochondrial |
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| Synonyms: | GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56271.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00390 |
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| Residue: | 522 |
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| Sequence: | MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
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| BDBM17657 |
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| n/a |
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| Name | BDBM17657 |
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| Synonyms: | (2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutamate | Glutamate | L-Glu | L-Glutamate | L-Glutamic acid | L-[14C(U)]glutamate | L-gluatmate |
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| Type | Amino Acid |
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| Emp. Form. | C5H9NO4 |
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| Mol. Mass. | 147.1293 |
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| SMILES | N[C@@H](CCC(O)=O)C(O)=O |
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| Structure | 
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