| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione reductase, mitochondrial |
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| Ligand | BDBM50352164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_767323 (CHEMBL1825435) |
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| Ki | 211±n/a nM |
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| Citation |  Çakmak, R; Durdagi, S; Ekinci, D; Sentürk, M; Topal, G Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Bioorg Med Chem Lett21:5398-402 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutathione reductase, mitochondrial |
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| Name: | Glutathione reductase, mitochondrial |
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| Synonyms: | GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56271.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00390 |
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| Residue: | 522 |
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| Sequence: | MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
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| BDBM50352164 |
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| n/a |
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| Name | BDBM50352164 |
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| Synonyms: | CHEMBL1824793 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N2O7 |
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| Mol. Mass. | 296.2329 |
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| SMILES | OC(=O)CC[C@H](NC(=O)c1ccc(cc1)[N+]([O-])=O)C(O)=O |r| |
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| Structure | 
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