| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA polymerase beta |
|---|
| Ligand | BDBM50356643 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_785333 (CHEMBL1921601) |
|---|
| IC50 | 11500±n/a nM |
|---|
| Citation |  Maruo, S; Kuriyama, I; Kuramochi, K; Tsubaki, K; Yoshida, H; Mizushina, Y Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Bioorg Med Chem19:5803-12 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA polymerase beta |
|---|
| Name: | DNA polymerase beta |
|---|
| Synonyms: | DNA Polymerase beta | DPOLB_RAT | Polb |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 38334.34 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1361926 |
|---|
| Residue: | 335 |
|---|
| Sequence: | MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGS
FRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQ
LPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
|
|
|
|---|
| BDBM50356643 |
|---|
| n/a |
|---|
| Name | BDBM50356643 |
|---|
| Synonyms: | CHEMBL1917198 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H38O4 |
|---|
| Mol. Mass. | 438.5989 |
|---|
| SMILES | CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12 |c:27| |
|---|
| Structure | 
|
|---|
Search and Browse
