| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase |
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| Ligand | BDBM50365447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_807435 (CHEMBL1960806) |
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| IC50 | 22±n/a nM |
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| Citation |  Kirubakaran, S; Gorla, SK; Sharling, L; Zhang, M; Liu, X; Ray, SS; Macpherson, IS; Striepen, B; Hedstrom, L; Cuny, GD Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett22:1985-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase |
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| Name: | Inosine-5'-monophosphate dehydrogenase |
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| Synonyms: | Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH) |
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| Type: | Protein |
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| Mol. Mass.: | 43076.80 |
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| Organism: | Cryptosporidium parvum |
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| Description: | Q8T6T2 |
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| Residue: | 400 |
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| Sequence: | MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAV
GMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNN
IDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIK
SKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSS
VASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYR
GMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLG
SASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
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| BDBM50365447 |
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| n/a |
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| Name | BDBM50365447 |
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| Synonyms: | CHEMBL1957257 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14Cl2N4O |
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| Mol. Mass. | 397.257 |
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| SMILES | Clc1ccc(NC(=O)Cn2c(nc3ccccc23)-c2ccccn2)cc1Cl |
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| Structure | 
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