| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50378936 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_809479 (CHEMBL2015334) |
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| IC50 | 5±n/a nM |
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| Citation |  Radeke, HS; Purohit, A; Harris, TD; Hanson, K; Jones, R; Hu, C; Yalamanchili, P; Hayes, M; Yu, M; Guaraldi, M; Kagan, M; Azure, M; Cdebaca, M; Robinson, S; Casebier, D Synthesis and Cardiac Imaging of (18)F-Ligands Selective for ß1-Adrenoreceptors. ACS Med Chem Lett2:650-655 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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| BDBM50378936 |
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| n/a |
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| Name | BDBM50378936 |
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| Synonyms: | CHEMBL2011236 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20FN3O4S |
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| Mol. Mass. | 393.433 |
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| SMILES | O[C@@H](CNCCNS(=O)(=O)c1ccccc1F)COc1ccccc1C#N |r| |
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| Structure | 
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