| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50379177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_810396 (CHEMBL2016217) |
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| EC50 | 489±n/a nM |
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| Citation |  Brocklehurst, KJ; Broo, A; Butlin, RJ; Brown, HS; Clarke, DS; Davidsson, Ö; Goldberg, K; Groombridge, SD; Kelly, EE; Leach, A; McKerrecher, D; O'Donnell, C; Poucher, S; Schofield, P; Scott, JS; Teague, J; Westgate, L; Wood, MJ Discovery, optimisation and in vivo evaluation of novel GPR119 agonists. Bioorg Med Chem Lett21:7310-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 36901.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TDV5 |
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| Residue: | 335 |
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| Sequence: | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
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| BDBM50379177 |
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| n/a |
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| Name | BDBM50379177 |
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| Synonyms: | CHEMBL2010834 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28F3N3O2 |
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| Mol. Mass. | 447.4932 |
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| SMILES | CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1 |
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| Structure | 
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