Reaction Details |
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Target | Serine/threonine-protein kinase haspin |
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Ligand | BDBM50778 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_812377 (CHEMBL2014113) |
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IC50 | 770±n/a nM |
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Citation | Cuny, GD; Ulyanova, NP; Patnaik, D; Liu, JF; Lin, X; Auerbach, K; Ray, SS; Xian, J; Glicksman, MA; Stein, RL; Higgins, JM Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett22:2015-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase haspin |
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Name: | Serine/threonine-protein kinase haspin |
Synonyms: | GSG2 | Germ cell-specific gene 2 protein | H-haspin | HASPIN | HASP_HUMAN | Haploid germ cell-specific nuclear protein kinase |
Type: | PROTEIN |
Mol. Mass.: | 88531.28 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1510616 |
Residue: | 798 |
Sequence: | MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQS
DDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRA
RPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSP
TPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRAS
LRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSC
QERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQ
KLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSEC
SNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLP
TEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISK
ELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLF
IVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT
SLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRT
MLNFSSATDLLCQHSLFK
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BDBM50778 |
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n/a |
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Name | BDBM50778 |
Synonyms: | (1S,2S,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(3-thienyl)-3,8a-dihydro-2H-indolizine-1-carboxylic acid ethyl ester | (1S,2S,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(3-thiophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylic acid ethyl ester | MLS000028120 | SMR000038911 | cid_658017 | ethyl (1S,2S,3R,8aS)-3-aminocarbonyl-1-cyano-6-ethanoyl-2-thiophen-3-yl-3,8a-dihydro-2H-indolizine-1-carboxylate | ethyl (1S,2S,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-thiophen-3-yl-3,8a-dihydro-2H-indolizine-1-carboxylate |
Type | Small organic molecule |
Emp. Form. | C19H19N3O4S |
Mol. Mass. | 385.437 |
SMILES | CCOC(=O)[C@]1(C#N)[C@@H]2C=CC(=CN2[C@H]([C@@H]1c1ccsc1)C(N)=O)C(C)=O |c:9,11| |
Structure |
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