| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Ligand | BDBM50379999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_810561 (CHEMBL2015311) |
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| IC50 | 1480±n/a nM |
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| Citation |  Ponaire, S; Zinglé, C; Tritsch, D; Grosdemange-Billiard, C; Rohmer, M Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents. Eur J Med Chem51:277-85 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Synonyms: | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_MYCS2 | dxr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41046.78 |
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| Organism: | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
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| Description: | ChEMBL_810561 |
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| Residue: | 398 |
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| Sequence: | MTTSAASGEPGRQRVLILGSTGSIGTQALEVIAANPDRFEVVGLAAGGGNPELLAAQRAQ
TGVAAVAVADPAAAEAVGDVRYSGPDAVTRLVEDTEADVVLNALVGALGLQPTLAALATG
ARLALANKESLVAGGPLVLKAAAPGQIVPVDSEHSAMAQCLRGGTRAELDKIVLTASGGP
FLGWSAEDLKSVTPEQAGKHPTWSMGPMNTLNSATLVNKGLELIETHLLFGVDYDDIDVV
VHPQSIVHSMATFTDGSTLAQASPPDMKLPIALALGWPDRIAGAAAACDFSTASTWEFLP
LDNAVFPAVDLARFAGKQGGCLTAVYNSANEEAAEAFLDGRIGFPDIVETVGDVLHAADR
WAAEPATVDDVLDAQRWAREQARGVVEQKSVRRGLVTK
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| BDBM50379999 |
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| n/a |
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| Name | BDBM50379999 |
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| Synonyms: | CHEMBL1161784 |
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| Type | Small organic molecule |
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| Emp. Form. | C4H10NO5P |
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| Mol. Mass. | 183.0997 |
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| SMILES | ONC(=O)CCCP(O)(O)=O |
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| Structure | 
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