| Reaction Details |
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 | Report a problem with these data |
| Target | Nucleotide-binding oligomerization domain-containing protein 2 |
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| Ligand | BDBM62294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_812916 (CHEMBL2020291) |
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| IC50 | >20000±n/a nM |
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| Citation |  Khan, PM; Correa, RG; Divlianska, DB; Peddibhotla, S; Sessions, EH; Magnuson, G; Brown, B; Suyama, E; Yuan, H; Mangravita-Novo, A; Vicchiarelli, M; Su, Y; Vasile, S; Smith, LH; Diaz, PW; Reed, JC; Roth, GP Identification of Inhibitors of NOD1-Induced Nuclear Factor-żB Activation. ACS Med Chem Lett2:780-785 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nucleotide-binding oligomerization domain-containing protein 2 |
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| Name: | Nucleotide-binding oligomerization domain-containing protein 2 |
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| Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115287.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454053 |
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| Residue: | 1040 |
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| Sequence: | MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWL
LSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLH
GCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQR
ARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTY
DGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGE
AGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQ
EDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNAR
KVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALH
GLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLL
RGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLE
FLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVA
ALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFH
SIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECA
ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECAL
HCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTS
LQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEEL
CLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRG
NTFSLEEVDKLGCRDTRLLL
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| BDBM62294 |
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| n/a |
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| Name | BDBM62294 |
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| Synonyms: | 4-[4-(1-propionylindolin-5-yl)sulfonylpiperazino]benzonitrile | 4-[4-[(1-propanoyl-2,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzenecarbonitrile | 4-[4-[(1-propanoyl-2,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzonitrile | 4-[4-[[1-(1-oxopropyl)-2,3-dihydroindol-5-yl]sulfonyl]-1-piperazinyl]benzonitrile | MLS-0412190.0001 | cid_44229060 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O3S |
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| Mol. Mass. | 424.516 |
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| SMILES | CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C#N |
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| Structure | 
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