Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50142317 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_813440 (CHEMBL2019336) |
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IC50 | 120±n/a nM |
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Citation | Basu, S; Prasad, UV; Barawkar, DA; De, S; Palle, VP; Menon, S; Patel, M; Thorat, S; Singh, UP; Das Sarma, K; Waman, Y; Niranjan, S; Pathade, V; Gaur, A; Reddy, S; Ansari, S Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett22:2843-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50142317 |
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n/a |
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Name | BDBM50142317 |
Synonyms: | (2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluoromethylphosphonic acid | CHEMBL8758 | {[2-Bromo-4-(3-oxo-2,3-diphenyl-propyl)-phenyl]-difluoro-methyl}-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C22H18BrF2O4P |
Mol. Mass. | 495.25 |
SMILES | OP(O)(=O)C(F)(F)c1ccc(CC(C(=O)c2ccccc2)c2ccccc2)cc1Br |
Structure |
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