Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50380989 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_814101 (CHEMBL2020695) | ||
Ki | 3900±n/a nM | ||
Citation | Fournier, PA; Arbour, M; Cauchon, E; Chen, A; Chefson, A; Ducharme, Y; Falgueyret, JP; Gagné, S; Grimm, E; Han, Y; Houle, R; Lacombe, P; Lévesque, JF; MacDonald, D; Mackay, B; McKay, D; Percival, MD; Ramtohul, Y; St-Jacques, R; Toulmond, S Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorg Med Chem Lett22:2670-4 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50380989 | |||
n/a | |||
Name | BDBM50380989 | ||
Synonyms: | CHEMBL2017099 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H15BrCl2F2N2O2 | ||
Mol. Mass. | 504.152 | ||
SMILES | O[C@@]1(CCNC[C@@H]1c1onc(c1Br)-c1c(Cl)cccc1Cl)c1ccc(F)c(F)c1 |r,wU:1.0,6.7,(-7.87,-30.01,;-6.37,-30.42,;-7.7,-31.2,;-7.7,-32.74,;-6.37,-33.5,;-5.04,-32.74,;-5.04,-31.2,;-3.83,-30.25,;-3.87,-28.71,;-2.43,-28.19,;-1.48,-29.4,;-2.34,-30.68,;-1.82,-32.12,;.06,-29.35,;.78,-27.99,;-.04,-26.69,;2.31,-27.93,;3.14,-29.25,;2.41,-30.6,;.87,-30.66,;.15,-32.01,;-6.37,-28.88,;-7.7,-28.12,;-7.71,-26.58,;-6.37,-25.8,;-6.37,-24.26,;-5.03,-26.57,;-3.7,-25.8,;-5.03,-28.11,)| | ||
Structure |