| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50381427 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814571 (CHEMBL2021090) |
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| IC50 | 66±n/a nM |
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| Citation |  Fernandez, MC; Escribano, A; Mateo, AI; Parthasarathy, S; Martin de la Nava, EM; Wang, X; Cockerham, SL; Beyer, TP; Schmidt, RJ; Cao, G; Zhang, Y; Jones, TM; Borel, A; Sweetana, SA; Cannady, EA; Stephenson, G; Frank, S; Mantlo, NB Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors. Bioorg Med Chem Lett22:3056-62 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50381427 |
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| n/a |
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| Name | BDBM50381427 |
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| Synonyms: | CHEMBL2017199 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29F9N8O2 |
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| Mol. Mass. | 668.5572 |
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| SMILES | CC[C@@H]1C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2nnn(CCN)n2)c2nc(ccc2N1C(=O)OC(C)C)C(F)(F)F |r| |
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| Structure | 
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