| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acylamino-acid-releasing enzyme |
|---|
| Ligand | BDBM50382729 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_817870 (CHEMBL2027518) |
|---|
| IC50 | 98000±n/a nM |
|---|
| Citation |  Sandomenico, A; Russo, A; Palmieri, G; Bergamo, P; Gogliettino, M; Falcigno, L; Ruvo, M Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation. J Med Chem55:2102-11 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acylamino-acid-releasing enzyme |
|---|
| Name: | Acylamino-acid-releasing enzyme |
|---|
| Synonyms: | AARE | ACPH_PIG | APEH | APH | Acyl-peptide hydrolase | Acylaminoacyl-peptidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 81230.60 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_817870 |
|---|
| Residue: | 732 |
|---|
| Sequence: | MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGRYRTVHTEWTQRDLERMEN
IRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTGTAEEKQF
LEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVADKKRPKAESFFQTK
ALDVTGSDDEMARTKKPDQAIKGDQFLFYEDWGENMVSKSTPVLCVLDIESGNISVLEGV
PESVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLTGGKCELLSDESV
AVTSPRLSPDQCRIVYLRFPSLVPHQQCGQLCLYDWYTRVTSVVVDIVPRQLGEDFSGIY
CSLLPLGCWSADSQRVVFDSPQRSRQDLFAVDTQMGSVTSLTAGGSGGSWKLLTIDRDLM
VVQFSTPSVPPSLKVGFLPPAGKEQAVSWVSLEEAEPFPDISWSIRVLQPPPQQEHVQYA
GLDFEAILLQPSNSPEKTQVPMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGS
TGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDAGRVALMGGSHGGFLSCHLIGQY
PETYSACVVRNPVINIASMMGSTDIPDWCMVEAGFSYSSDCLPDLSVWAAMLDKSPIKYA
PQVKTPLLLMLGQEDRRVPFKQGMEYYRVLKARNVPVRLLLYPKSTHALSEVEVESDSFM
NAVLWLCTHLGS
|
|
|
|---|
| BDBM50382729 |
|---|
| n/a |
|---|
| Name | BDBM50382729 |
|---|
| Synonyms: | CHEMBL2023560 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H36F3N7O5S |
|---|
| Mol. Mass. | 591.647 |
|---|
| SMILES | CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)C(F)(F)F)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
