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TargetRelaxin-3 receptor 1
LigandBDBM50382995
Substrate/Competitorn/a
Meas. Tech.ChEMBL_818425 (CHEMBL2034745)
Ki>10000±n/a nM
Citation Shabanpoor, F; Akhter Hossain, M; Ryan, PJ; Belgi, A; Layfield, S; Kocan, M; Zhang, S; Samuel, CS; Gundlach, AL; Bathgate, RA; Separovic, F; Wade, JD Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. J Med Chem55:1671-81 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Relaxin-3 receptor 1
Name:Relaxin-3 receptor 1
Synonyms:G protein-coupled receptor SALPR | G-protein coupled receptor GPCR135 | GPCR135 | RL3R1_HUMAN | RLN3 receptor 1 | RLN3R1 | RXFP3 | Relaxin family peptide receptor 3 | SALPR | Somatostatin- and angiotensin-like peptide receptor
Type:PROTEIN
Mol. Mass.:51139.41
Organism:Homo sapiens (Human)
Description:ChEMBL_818423
Residue:469
Sequence:
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGA
PPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLF
VTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTR
YHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVK
VMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAA
GTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFS
QEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTA
TTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
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  Blast E-value cutoff:
BDBM50382995
n/a
NameBDBM50382995
Synonyms:CHEMBL2030693
TypeSmall organic molecule
Emp. Form.C128H205N43O33S4
Mol. Mass.3002.526
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r,wU:90.92,83.83,71.80,63.63,44.48,14.19,4.4,126.128,137.138,156.158,157.161,177.179,194.196,100.102,wD:95.97,52.59,38.40,23.30,8.10,2.2,115.116,131.132,138.140,145.146,163.165,183.185,(34,-26.45,;34,-27.99,;35.34,-28.76,;36.66,-27.99,;35.34,-30.3,;34,-31.08,;32.66,-30.31,;32.66,-28.76,;31.33,-31.08,;31.33,-32.62,;32.66,-33.39,;30,-30.31,;28.66,-31.08,;28.66,-32.62,;27.33,-30.31,;27.33,-28.77,;28.66,-28,;28.66,-26.46,;27.32,-25.69,;29.99,-25.69,;26,-31.08,;24.67,-30.32,;24.67,-28.77,;23.33,-31.09,;23.33,-32.62,;24.67,-33.4,;24.67,-34.93,;26,-35.7,;26,-37.24,;24.67,-38.01,;27.34,-38.01,;22,-30.32,;20.67,-31.09,;20.67,-32.63,;19.33,-30.33,;17.99,-31.1,;16.66,-30.32,;16.66,-28.79,;15.32,-31.1,;15.32,-32.64,;16.66,-33.4,;13.99,-30.33,;12.67,-31.1,;12.67,-32.64,;11.32,-30.33,;11.32,-28.79,;12.67,-28.02,;12.67,-26.48,;13.99,-28.79,;9.99,-31.11,;8.66,-30.34,;8.66,-28.79,;7.32,-31.11,;7.32,-32.65,;8.66,-33.42,;8.66,-34.95,;9.99,-35.73,;9.99,-37.26,;8.67,-38.03,;11.34,-38.03,;5.99,-30.34,;4.65,-31.11,;4.65,-32.65,;3.32,-30.34,;1.99,-31.11,;.67,-30.35,;.67,-28.8,;-.68,-31.12,;-2.01,-30.35,;-3.34,-31.12,;-3.34,-32.66,;-4.68,-30.35,;-4.68,-28.81,;-3.34,-28.04,;-2.04,-28.8,;-.69,-28.03,;-.71,-26.49,;.62,-25.72,;-2.04,-25.72,;-3.36,-26.5,;-6.02,-31.12,;-7.35,-30.35,;-8.69,-31.13,;-7.35,-28.82,;-5.96,-28.11,;-6.51,-26.51,;-8.18,-26.53,;-8.68,-28.13,;-9.98,-28.97,;-9.98,-30.52,;-11.32,-28.2,;-11.31,-26.66,;-12.66,-28.96,;-13.99,-28.19,;-13.98,-26.65,;-15.33,-28.95,;-15.34,-30.49,;-16.66,-28.17,;-17.99,-28.94,;-18,-30.48,;-19.32,-28.16,;-20.66,-28.93,;-19.33,-26.62,;-20.65,-25.85,;-20.66,-24.31,;-21.98,-23.54,;-21.99,-22,;-23.32,-21.23,;-20.65,-21.23,;3.32,-28.8,;4.65,-28.03,;1.99,-28.03,;36.66,-31.07,;36.66,-32.61,;38.01,-30.3,;39.32,-31.07,;39.32,-32.6,;40.66,-33.37,;40.66,-34.92,;42,-35.68,;42,-37.22,;40.67,-37.99,;43.34,-38,;40.66,-30.29,;40.66,-28.76,;42,-31.06,;43.33,-30.3,;43.33,-28.75,;44.66,-31.06,;44.66,-32.6,;46,-30.29,;47.33,-31.06,;47.33,-32.59,;48.67,-33.37,;48.67,-30.29,;48.67,-28.74,;50,-31.05,;51.33,-30.28,;51.33,-28.74,;52.66,-27.97,;50,-27.97,;50,-26.43,;52.66,-31.05,;52.66,-32.59,;54,-30.28,;55.33,-31.05,;55.33,-32.59,;56.67,-33.36,;58,-32.58,;59.33,-33.35,;59.34,-34.89,;58,-35.66,;56.67,-34.89,;56.67,-30.28,;56.67,-28.73,;58,-31.05,;59.33,-30.27,;59.33,-28.73,;58,-27.96,;60.67,-27.96,;60.67,-31.04,;60.67,-32.58,;62.01,-30.27,;63.33,-31.04,;63.33,-32.57,;64.67,-33.34,;64.67,-30.26,;64.67,-28.73,;66,-31.03,;67.34,-30.27,;68.67,-31.03,;68.67,-32.57,;70,-30.26,;71.33,-31.03,;72.67,-30.26,;72.67,-28.71,;74,-31.02,;75.34,-30.25,;75.34,-28.71,;76.67,-27.94,;76.67,-31.02,;76.67,-32.56,;78,-30.25,;79.33,-31.02,;79.33,-32.56,;80.67,-33.33,;80.67,-34.86,;82.01,-35.64,;82.01,-37.17,;80.68,-37.94,;83.35,-37.94,;80.67,-30.25,;80.67,-28.7,;82.01,-31.02,;83.34,-30.24,;83.34,-28.7,;84.67,-27.93,;86.08,-28.55,;87.11,-27.41,;86.33,-26.08,;86.81,-24.61,;85.78,-23.46,;84.27,-23.79,;83.8,-25.25,;84.83,-26.4,;84.67,-31.01,;86,-30.24,;84.67,-32.55,)|
Structure
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