Reaction Details |
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Target | Smoothened homolog |
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Ligand | BDBM50383023 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_818642 (CHEMBL2033031) |
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IC50 | 290±n/a nM |
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Citation | Solinas, A; Faure, H; Roudaut, H; Traiffort, E; Schoenfelder, A; Mann, A; Manetti, F; Taddei, M; Ruat, M Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem55:1559-71 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Smoothened homolog |
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Name: | Smoothened homolog |
Synonyms: | G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog |
Type: | Protein |
Mol. Mass.: | 86415.51 |
Organism: | Homo sapiens (Human) |
Description: | Q99835 |
Residue: | 787 |
Sequence: | MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
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BDBM50383023 |
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n/a |
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Name | BDBM50383023 |
Synonyms: | CHEMBL2031282 |
Type | Small organic molecule |
Emp. Form. | C24H24N4O5 |
Mol. Mass. | 448.4712 |
SMILES | COc1cc(cc(OC)c1OC)C(=O)NC(N)=Nc1cccc(NC(=O)c2ccccc2)c1 |w:17.18| |
Structure |
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