| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50383459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_818296 (CHEMBL2034344) |
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| Ki | 2.6±n/a nM |
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| Citation |  Xiao, D; Palani, A; Sofolarides, M; Aslanian, R; West, RE; Williams, SM; Wu, RL; Hwa, J; Sondey, C; Lachowicz, J; Korfmacher, WA Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists. Bioorg Med Chem Lett22:3354-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_MOUSE | Hrh3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48560.37 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_988451 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50383459 |
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| n/a |
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| Name | BDBM50383459 |
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| Synonyms: | CHEMBL2031619 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N6OS |
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| Mol. Mass. | 396.509 |
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| SMILES | O=c1ccnc2c(cccn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1 |
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| Structure | 
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