| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM19817 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_821153 (CHEMBL2039695) |
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| IC50 | 26000±n/a nM |
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| Citation |  Stumpfe, D; Bajorath, J Exploring activity cliffs in medicinal chemistry. J Med Chem55:2932-42 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM19817 |
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| n/a |
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| Name | BDBM19817 |
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| Synonyms: | (1R,2R)-N-(cyanomethyl)-2-[(phenylsulfanyl)methyl]cyclohexane-1-carboxamide | Cyclohexanecarboxamide derivative, 12a | racemic mixture |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N2OS |
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| Mol. Mass. | 288.408 |
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| SMILES | O=C(NCC#N)[C@@H]1CCCC[C@H]1CSc1ccccc1 |r| |
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| Structure | 
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