Reaction Details |
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Target | Thioredoxin reductase 1, cytoplasmic |
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Ligand | BDBM50385280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_822563 (CHEMBL2039583) |
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IC50 | 1590±n/a nM |
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Citation | He, J; Li, D; Xiong, K; Ge, Y; Jin, H; Zhang, G; Hong, M; Tian, Y; Yin, J; Zeng, H Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy. Bioorg Med Chem20:3816-27 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thioredoxin reductase 1, cytoplasmic |
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Name: | Thioredoxin reductase 1, cytoplasmic |
Synonyms: | NADPH-dependent thioredoxin reductase | TR | TRXR1_RAT | Thioredoxin reductase TR1 | Trxr1 | Txnrd1 |
Type: | PROTEIN |
Mol. Mass.: | 54519.34 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_589950 |
Residue: | 498 |
Sequence: | MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCG
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BDBM50385280 |
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n/a |
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Name | BDBM50385280 |
Synonyms: | CHEMBL2035483 |
Type | Small organic molecule |
Emp. Form. | C19H16Br2N2O2Se2 |
Mol. Mass. | 622.07 |
SMILES | Brc1ccc2[se]n(CCCCCn3[se]c4ccc(Br)cc4c3=O)c(=O)c2c1 |
Structure |
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