| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Quinolone resistance protein NorA |
|---|
| Ligand | BDBM11639 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_826866 (CHEMBL2051681) |
|---|
| IC50 | >40000±n/a nM |
|---|
| Citation |  Sabatini, S; Gosetto, F; Serritella, S; Manfroni, G; Tabarrini, O; Iraci, N; Brincat, JP; Carosati, E; Villarini, M; Kaatz, GW; Cecchetti, V Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors. J Med Chem55:3568-72 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Quinolone resistance protein NorA |
|---|
| Name: | Quinolone resistance protein NorA |
|---|
| Synonyms: | NORA_STAAU | norA |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42273.03 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | ChEMBL_961221 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
|
|
|
|---|
| BDBM11639 |
|---|
| n/a |
|---|
| Name | BDBM11639 |
|---|
| Synonyms: | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide | CHEMBL118 | CLX | Celebrex | Celecoxib | US10322118, Urea-Based Scaffold Entry 9 | US11478464, Compound Celecoxib | US11786535, Compound Celecoxib | US8741944, Comparative Compound | US9388139, Celecoxib | cid_2662 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14F3N3O2S |
|---|
| Mol. Mass. | 381.372 |
|---|
| SMILES | Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
