Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 1 |
---|
Ligand | BDBM50386662 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_826884 (CHEMBL2051699) |
---|
IC50 | 71.2±n/a nM |
---|
Citation | Lai, MJ; Huang, HL; Pan, SL; Liu, YM; Peng, CY; Lee, HY; Yeh, TK; Huang, PH; Teng, CM; Chen, CS; Chuang, HY; Liou, JP Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo. J Med Chem55:3777-91 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 1 |
---|
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
BDBM50386662 |
---|
n/a |
---|
Name | BDBM50386662 |
Synonyms: | CHEMBL2048755 |
Type | Small organic molecule |
Emp. Form. | C18H16N2O2 |
Mol. Mass. | 292.3318 |
SMILES | ONC(=O)\C=C\c1ccc2n(Cc3ccccc3)ccc2c1 |
Structure |
|