Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50386658 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_826885 (CHEMBL2051700) |
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IC50 | 361.8±n/a nM |
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Citation | Lai, MJ; Huang, HL; Pan, SL; Liu, YM; Peng, CY; Lee, HY; Yeh, TK; Huang, PH; Teng, CM; Chen, CS; Chuang, HY; Liou, JP Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo. J Med Chem55:3777-91 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50386658 |
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n/a |
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Name | BDBM50386658 |
Synonyms: | CHEMBL2048749 |
Type | Small organic molecule |
Emp. Form. | C18H16N2O5S |
Mol. Mass. | 372.395 |
SMILES | COc1ccc(cc1)S(=O)(=O)n1ccc2cc(\C=C\C(=O)NO)ccc12 |
Structure |
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