Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50387136 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_827865 (CHEMBL2051274) |
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Ki | 46±n/a nM |
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Citation | Winum, JY; Carta, F; Ward, C; Mullen, P; Harrison, D; Langdon, SP; Cecchi, A; Scozzafava, A; Kunkler, I; Supuran, CT Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines. Bioorg Med Chem Lett22:4681-5 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50387136 |
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n/a |
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Name | BDBM50387136 |
Synonyms: | 4-ureidophenyl sulfamate ring derivative 3u | CHEMBL2047816 |
Type | Small organic molecule |
Emp. Form. | C17H23N3O4S |
Mol. Mass. | 365.447 |
SMILES | NS(=O)(=O)Oc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 |TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13| |
Structure |
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