| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50133018 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_828300 (CHEMBL2050319) |
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| Ki | 6.31±n/a nM |
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| Citation |  Engelhardt, H; de Esch, IJ; Kuhn, D; Smits, RA; Zuiderveld, OP; Dobler, J; Mayer, M; Lips, S; Arnhof, H; Scharn, D; Haaksma, EE; Leurs, R Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands. Eur J Med Chem54:660-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50133018 |
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| n/a |
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| Name | BDBM50133018 |
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| Synonyms: | (4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone | (4,5-dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL129436 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15Cl2N3O |
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| Mol. Mass. | 312.194 |
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| SMILES | CN1CCN(CC1)C(=O)c1cc2c(Cl)c(Cl)ccc2[nH]1 |
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| Structure | 
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