Reaction Details |
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Target | Protein arginine N-methyltransferase 1 [11-371] |
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Ligand | BDBM50387483 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_828306 (CHEMBL2050325) |
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IC50 | 368300±n/a nM |
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Citation | Sinha, SH; Owens, EA; Feng, Y; Yang, Y; Xie, Y; Tu, Y; Henary, M; Zheng, YG Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents. Eur J Med Chem54:647-59 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 1 [11-371] |
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Name: | Protein arginine N-methyltransferase 1 [11-371] |
Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
Type: | Protein |
Mol. Mass.: | 41506.52 |
Organism: | Homo sapiens (Human) |
Description: | Q99873[11-371] |
Residue: | 361 |
Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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BDBM50387483 |
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n/a |
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Name | BDBM50387483 |
Synonyms: | CHEMBL2047481 |
Type | Small organic molecule |
Emp. Form. | C35H53N4 |
Mol. Mass. | 529.8205 |
SMILES | CC1(C)\C(=C\C=C/C2=[N+](CCC[N+](C)(C)C)c3ccccc3C2(C)C)N(CCC[N+](C)(C)C)c2ccccc12 |c:7| |
Structure |
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