| Reaction Details |
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 | Report a problem with these data |
| Target | Natural resistance-associated macrophage protein 1 |
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| Ligand | BDBM50387747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_830680 (CHEMBL2061615) |
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| IC50 | >10000±n/a nM |
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| Citation |  Zhang, Z; Kodumuru, V; Sviridov, S; Liu, S; Chafeev, M; Chowdhury, S; Chakka, N; Sun, J; Gauthier, SJ; Mattice, M; Ratkay, LG; Kwan, R; Thompson, J; Cutts, AB; Fu, J; Kamboj, R; Goldberg, YP; Cadieux, JA Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors. Bioorg Med Chem Lett22:5108-13 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Natural resistance-associated macrophage protein 1 |
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| Name: | Natural resistance-associated macrophage protein 1 |
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| Synonyms: | LSH | NRAM1_HUMAN | NRAMP | NRAMP 1 | NRAMP1 | SLC11A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59878.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_830680 |
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| Residue: | 550 |
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| Sequence: | MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWA
FTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKD
LGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVD
TFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPE
LLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINL
FVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAA
LYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRD
LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAIN
LYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLL
EEDQKGETSG
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| BDBM50387747 |
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| n/a |
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| Name | BDBM50387747 |
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| Synonyms: | CHEMBL2058607 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16F2N4S3 |
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| Mol. Mass. | 398.517 |
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| SMILES | NC(=N)SCc1ccccc1Sc1cc(F)c(F)cc1CSC(N)=N |
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| Structure | 
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