Ki Summary

Reaction Details

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Target

Subtilisin-like protease 1

Ligand

BDBM50388061

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_830092 (CHEMBL2061883)

IC50

40000±n/a nM

Citation

Gemma, S; Giovani, S; Brindisi, M; Tripaldi, P; Brogi, S; Savini, L; Fiorini, I; Novellino, E; Butini, S; Campiani, G; Penzo, M; Blackman, MJ Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. Bioorg Med Chem Lett22:5317-21 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Subtilisin-like protease 1

Name:

Subtilisin-like protease 1

Synonyms:

SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1

Type:

PROTEIN

Mol. Mass.:

77866.88

Organism:

Plasmodium falciparum

Description:

ChEMBL_830092

Residue:

690

Sequence:

MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKS
NIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSS
SSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNI
NSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVN
DYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLY
DDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELI
NEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNN
SGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDY
CISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSI
NAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNS
YRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADIN
KAVNLAIKSKKTYINSNISNKWKKKSRYLH

BDBM50388061

n/a

Name

BDBM50388061

Synonyms:

CHEMBL2057540

Type

Small organic molecule

Emp. Form.

C18H14N4O4

Mol. Mass.

350.3282

SMILES

Cc1cc(N=NCc2ccccc2[N+]([O-])=O)c2cc3OCOc3cc2n1 |w:4.3|

Structure