Reaction Details |
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Target | Carboxylic ester hydrolase |
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Ligand | BDBM10622 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_829364 (CHEMBL2060155) |
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IC50 | 30000±n/a nM |
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Citation | Shinada, M; Narumi, F; Osada, Y; Matsumoto, K; Yoshida, T; Higuchi, K; Kawasaki, T; Tanaka, H; Satoh, M Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities. Bioorg Med Chem20:4901-14 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carboxylic ester hydrolase |
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Name: | Carboxylic ester hydrolase |
Synonyms: | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | BuChE | Butyrylcholinesterase (BuChE) | butyrylcholinesterase precursor |
Type: | Enzyme |
Mol. Mass.: | 67776.22 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 597 |
Sequence: | MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPP
LGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNV
WIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFP
GNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLF
TRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEK
LVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGF
SKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYN
IICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYT
RAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAP
QCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
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BDBM10622 |
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n/a |
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Name | BDBM10622 |
Synonyms: | (-)-Phenserine | (3aS)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-phenylcarbamate | CHEMBL54727 |
Type | Small organic molecule |
Emp. Form. | C20H23N3O2 |
Mol. Mass. | 337.4155 |
SMILES | CN1CC[C@]2(C)C1N(C)c1ccc(OC(=O)Nc3ccccc3)cc21 |r| |
Structure |
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