| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
|---|
| Ligand | BDBM50388990 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_832857 (CHEMBL2066619) |
|---|
| IC50 | 5.3±n/a nM |
|---|
| Citation |  Zhou, H; Chen, J; Meagher, JL; Yang, CY; Aguilar, A; Liu, L; Bai, L; Cong, X; Cai, Q; Fang, X; Stuckey, JA; Wang, S Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. J Med Chem55:4664-82 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apoptosis regulator Bcl-2 |
|---|
| Name: | Apoptosis regulator Bcl-2 |
|---|
| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
|---|
| Type: | Homodimer or heterodimer |
|---|
| Mol. Mass.: | 26269.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10415 |
|---|
| Residue: | 239 |
|---|
| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
|
|
|
|---|
| BDBM50388990 |
|---|
| n/a |
|---|
| Name | BDBM50388990 |
|---|
| Synonyms: | CHEMBL2063893 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C47H51ClN8O5S2 |
|---|
| Mol. Mass. | 907.541 |
|---|
| SMILES | CNC(=O)c1c(c(cn1C)-c1ccc(Cl)cc1)-c1cccc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN(C)C)CSc3ccccc3)c(c2)[N+]([O-])=O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
